The measurement of cholecystokinin.
نویسندگان
چکیده
منابع مشابه
The measurement of cholecystokinin.
Measurement of hormones in biological fluids is an obvious prerequisite for evaluation of their physiological and pathophysiological significance. Of the steadily increasing list of gastrointestinal hormones, cholecystokinin (CCK) was the third to be discovered (Ivy and Oldberg, 1928). Cholecystokinin, secretin, and gastrin constitute the classical triad of gut hormones which, until recently, w...
متن کاملMeasurement of Cholecystokinin
Early measurements of cholecystokinin (CCK) were based on the abilities of blood or blood extracts to stimulate gallbladder contraction or pancreatic exocrine secretion. These biological assays were performed in laboratory animals such as dogs, pigs or rodents. The usefulness of these assays was limited because methods were cumbersome and interpretation of results was complicated by confounding...
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Shortage of reliable plasma assays has hampered studies of cholecystokinin (CCK). The assay problems are low plasma concentrations, extensive molecular heterogeneity, and close homology of CCK to gastrin, which circulates in higher concentrations. To develop an accurate CCK RIA, antibodies were raised in rabbits, guinea pigs, and mice in titers from 200 to 4000000. The specificity of the antise...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1978
ISSN: 0021-9746
DOI: 10.1136/jcp.s1-8.1.26